Massacre at Vassy, French Religious Wars, 1 March 1562 (1570). Francois de Lorraine, 2nd Duc de Guise (1519-1563), directs massacre of Huguenots during a service, watched by Charles de Lorraine, Cardinal Guise (1525-1574), (top left). The massacre sparked the French Religious Wars between the Catholics and the Protestant Huguenots which took place between 1562 and 1598. The conflict ended when Henry IV issued the Edict of Nantes, granting Protestants and Catholics equal rights.
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